Great Mountain Views. Huerfano County, tucked away in Colorado's southwest, has an inviting atmosphere for those that are eager to disconnect from the busy life and recharge. The low cost of living, rich culture, and beautiful natural landscape makes for endless possibilities in Huerfano County. Walk, hike, bike, fish, boat or climb landscapes that enrich the soul. Walsenburg is located in east-central Huerfano County, on the north side of the Cucharas River at the eastern edge of the foothills of the Sangre de Cristo Mountains. Interstate 25 runs along the eastern edge of the city, with access from Exits 49, 50, and 52. I-25 leads north 48 miles (77 km) to Pueblo and south 36 miles (58 km) to Trinidad. U.S. Route 160 passes through the center of Walsenburg, leading west across North La Veta Pass 72 miles (116 km) to Alamosa and south with I-25 to Trinidad. Colorado State Highway 10 leads northeast from Walsenburg 73 miles (117 km) to La Junta.